Adipocytokines leptin and adiponectin function as mast cell activity modulators

Serum levels of adipocytokines, adiponectin and leptin, in patients with obstructive sleep apnea syndrome.

OBJECTIVE Obstructive sleep apnea syndrome (OSAS) is frequently complicated by metabolic syndrome, including diabetes and hypertension. Both OSAS and metabolic syndrome are strongly associated with obesity. Recently, adiponectin and leptin, which are secreted by adipose tissue, have been considered to play important roles in the progression of these diseases. Thus, to examine the association be...

Thrombospondins as matricellular modulators of cell function.

Effect of psoriasis activity on serum adiponectin and leptin levels

INTRODUCTION Psoriasis is an inflammatory and chronic skin disease associated with obesity, cardiovascular diseases, diabetes and metabolic syndrome. Adipokines, as bioactive substances secreted from adipose tissue, are involved in various metabolic diseases. AIM To investigate the association between psoriasis severity and serum adiponectin and leptin levels in patients with psoriasis. MAT...

Mast cells as mediators and modulators of atherogenesis.

The central role of inflammation in atherogenesis has gained broad acceptance and has revolutionized our understanding of this common disease. This recognition has heightened interest in identifying the specific mediators and mechanisms that contribute to the interplay between risk factors (traditional and emerging), inflammation, and the altered biology of the arterial wall that regulates plaq...

Mast Cell Function

Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as effectors of allergy. It has been only in the past two decades that mast cells have gained recognition for their involvement in other physiological and pathological processes. Mast cells have a widespread distribution and are found predominantly at the interface between the host and the external environment. Ma...